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The current work, which attributes the pathophysiology of envenomation to oxidative stress, is further supported by several studies that focused on the role of oxidative stress in the pathophysiology of snake envenomation

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At ~5382 Da, FOXO4-DRI is above the typical renal filtration threshold (~60 kDa for globular proteins, but much lower for linear peptides), suggesting renal clearance may contribute to elimination