L.SkibickaK
On the heels of basic research on the venom of Gila monsters in the preceding decades,1 exenatide secured the first US FDA approval in the class on April 28, 2005.2 While the prominent GLP-1 brand names are household names today, the class was off to a relatively slow start at first five years passed before it reached blockbuster status (US$1 billion (770 million) in sales), and another five went by before the first formal approval of a GLP-1 drug indicated for obesity became a reality.3 Last year saw sales for the class cross $50 billion and, with another 40% in revenue growth in store for 2025, the GLP-1 segment of the pharmaceutical industry is firmly in the rapid growth phase of the market, per Investment Bank Consensus
Be aware of the following symptoms: Fatigue Cold sweat Nausea Chest pain Dizziness Shortness of breath Pain in the jaw, neck, arms, shoulder, or back Call 911 if you or someone you know is having a heart attack
Anything earlier would require priority review, which is possible but not the default for obesity
Hypoglycemia Increased heart rate Potential pancreatitis Gallbladder issues Acute kidney injury Risk of thyroid tumors It is recommended that patients be monitored for these risks, especially those with a history of thyroid disease
Product Features Strip plates and additional reagents allow for use in multiple experiments Quantitative protein detection Establishes normal range The best products for confirmation of antibody array data Kit Components Pre-Coated 96-well Strip Microplate Wash Buffer Lyophilized Standard Capture Antibody Assay Diluent Biotinylated Peptide HRP-Streptavidin Positive Control TMB One-Step Substrate Reagent Stop Solution Additional Materials Required Microplate reader capable of measuring absorbance at 450 nm Precision pipettes to deliver 2 L to 1 mL volumes Adjustable 1-25 mL pipettes for reagent preparation 100 mL and 1-liter graduated cylinders Absorbent paper Distilled or deionized water Software which can perform four-parameter logistic regression models Tubes to prepare standard or sample dilutions Orbital shaker Aluminum foil Plastic wrap Assay Procedure Summary Prepare all reagents, samples and standards as instructed
