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EMS-induced oxidative stress generates reactive oxygen species, and an increase in reactive oxygen species in the follicle leads to spindle instability, aberrant chromosomal formation, and impaired oocyte developmental capability (98)

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270 More importantly, p53 is regulated only in AgRP neurons and not in major neuronal populations of the arcuate nucleus of the hypothalamus (ARC), which suggests that p53 alterations associated with energy balance are nucleus-specific

Available from: /pmc/articles/PMC3700085/?report=abstract Zhang F, Li R, Yan M, Li Q, Li Y, Wu X

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Access is currently limited to clinical trial enrolment or, informally, research peptide suppliers (which carries significant legal and safety risks)