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This process is driven by the failure of cellular antioxidant defenses, particularly the GPX4 system, which neutralizes typically lipid peroxides using glutathione (GSH) [86, 87]

10.1007/s11154-020-09591-9594 Rev

Excitotoxicity Excitotoxicity can cause neural death caused by massive secretion of excitatory neurotransmitters under many neuropathological conditions, including TBI [34,35], where increased concentrations of glutamate are secreted and released into the extracellular space owing to cellular lysis and a subsequent increase in positive charges within the cell [36]

Un maillon du rseau antioxydant : le GSH intervient dans des ractions naturelles de conjugaison (phase II) et prsente des interactions mtaboliques avec d'autres antioxydants alimentaires, comme les vitamines C et E