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Report any unusual symptoms to your doctor, including persistent muscle pain, joint pain, skin changes, or new digestive symptoms

We demonstrate that the therapeutic potential of GLP-1RAs in RA is mediated by their dual targeting of two key pathological pathways: suppressing a previously unidentified cGAS-STING-ferroptosis axis in chondrocytes and reprogramming synovial macrophages toward an M2 reparative phenotype, which collectively helps maintain joint homeostasis

The symptoms include anorexia, weight loss, muscle loss, skeletal muscle atrophy, anemia, and alterations in carbohydrate, lipid, and protein metabolism [6]

Severe symptoms may involve seizures and delirium, highlighting the dangers of abrupt cessation without medical guidance

Another important pathway involving GSTM1 is the glutathione metabolism pathway

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