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Regulatory Toxicology and Pharmacology 46 (1): 23-8

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Another 2025 survey published in JAMA Health Forum noted that, should Medicare pay for the drugs, it could avoid spending a hypothetical $18.2 billion on obesity-related health expenditures over 10 years while dishing out $65.9 billion annually on the GLP-1s by year 10, thereby negating any savings

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While their mechanisms may differ, their combination has been proposed to provide complementary or synergistic actions