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Collectively, our study identifies the L2HGDH-L2HG axis as a previously unrecognized metabolic checkpoint controlling ferroptosis sensitivity in liver cancer and uncovers glutathione degradation as a therapeutically exploitable vulnerability for ferroptosis-based treatment strategies in HCC
Selenium nanoparticles alleviate ischemia reperfusion injury-induced acute kidney injury by modulating GPx-1/NLRP3/caspase-1 pathway
For cell-based experiments, a minimum of three biological replicates were used
Anyone with G6PD deficiency, active chemotherapy, transplant immunosuppression, severe liver or kidney disease, or those pregnant/breastfeeding should avoid supplementation without explicit medical approval
However, standard oral glutathione (GSH) supplements are degraded during digestion and therefore are poorly absorbed
Cruciferous vegetables (broccoli, Brussels sprouts, cauliflower) Alliums (garlic, onions, leeks) Lean proteins containing cysteine Foods high in Vitamin C (to help regenerate glutathione) Step 4: Stay Consistent Wellness is built through daily habits rather than occasional intensity
