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Typically, the initial effects of GLP-1 agonists on blood sugar control become apparent within the first week of treatment

For those with diabetes, monitoring should include blood glucose checks as clinically indicated and hemoglobin A1c reassessment approximately 3 months after therapy changes, per American Diabetes Association guidelines

Most patients experience peak nausea during the first 48 weeks, which resolves or becomes manageable with continued use

This is why long-term weight maintenance typically requires either continued medication use or substantial lifestyle modifications

Risk of erectile dysfunction One of the more serious concerns is the risk of sexual dysfunction (ED)