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Despite being quadrupedal for locomotion, cynomolgus monkeys also spend large amounts of time in semierect and erect positions and exhibit characteristics that more closely mimic humans, including IVD size, anatomy, spontaneous disc degeneration, and exposure to mechanical stresses compatible with erect posture

IL-4 secreted by activated T cells has anti-angiogenic effects by inhibiting VEGF production in RA FLS, which helps relieve RA (88)

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