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In patients with pre- existing seizure activity, an increase in seizure frequency and/or severity has been reported

Di Cesare Mannelli L, Ghelardini C, Toscano A, Pacini A, Bartolini A (2010) The neuropathy-protective agent acetyl-L-carnitine activates protein kinase C-gamma and MAPKs in a rat model of neuropathic pain

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Additionally, phenolic compounds in plants are present in relatively low concentrations and easily degraded by light and heat, which reduces their bioactivity 219

Chronic exposure to pollutants, heavy metals, and endocrine-disrupting chemicals, as well as lifestyle habits such as smoking, an ultra-processed diet, and chronic stress, leads to redox imbalance in both oocytes and the ovarian microenvironment