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25 As an endocrine hormone, GLP-1 is secreted by enteroendocrine L-cells in the distal jejunum, ileum, and colon in response to food intake and neuroendocrine signals

These were human subjects in a randomized controlled trial

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Where it works: Hypothalamus: Reduces hunger signals in the appetite control center of the brain Pancreas: Stimulates insulin secretion from beta cells when blood sugar rises Stomach: Slows gastric emptying, keeping you fuller longer Weight loss contribution: GLP-1 activation is responsible for the majority of appetite suppression

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