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The Morris water maze, a hippocampal-dependent spatial learning task requiring rats to locate a pedestal hidden beneath the surface of the water by orienting themselves to extra- maze cues was employed to evaluate the impact of the HGF antagonist, Hinge, on the pro- cognitive effects of Dihexa

In some embodiments, the auris-acceptable penetration enhancer is a surfactant comprising an alkyl-glycoside wherein the alkyl glycoside is tetradecyl--D-maltoside

Microdosing protocols might use 0.5mg or 1mg

Cait and colleagues note that activation of Podxl may assist with decreasing the permeability of the BBB in diseases such as multiple sclerosis or stroke, whereas increasing the permeability may help with temporarily opening the BBB to allow therapeutics to reach brain tissue

Your provider will recommend frequency and options based on your needs