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Moreover, TGF- negatively regulates c-MET and HGF mRNA levels in human squamous carcinoma cells 49

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The neurotrophic agents capable of facilitating synaptogenesis and neurogenesis include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3, and neurotrophin-4 [34,35]

FOXO4-DRI is a breakthrough "third-generation" senolytic peptide engineered to selectively eliminate senescent cells ("zombie cells") that accumulate with aging

Thus dosage, pharmacokinetics, long-term safety, off-target effects in humans remain unknown

Canakinumab in the treatment of erosive hand osteoarthritis: a case series