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Oxidative stress is crucial in atherogenesis (144151), suggesting that a specific antioxidant/prooxidant imbalance, characterized by a weak GSH-related enzymatic antioxidant shield present in human atherosclerotic lesions, may be involved in atherogenic processes in humans (152)

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The path forward for cortistatin likely requires development of selective analogs with improved pharmacokinetics and a clinically feasible administration route