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Although current evidence supports broad applicability across BMI, diabetes status, and fibrosis stages F2-F3, subgroup analyses suggest attenuated responses in non-obese patients and in certain ethnic groups (Hispanic patients in ESSENCE), emphasizing the need for precision medicine approaches incorporating anthropometric, genetic (e.g., PNPLA3, HSD17B13), and metabolic profiling

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Over time, consistent use may contribute to: Smoother skin texture Improved skin tone Better hydration retention Reduced appearance of fine lines Increased skin resilience Healthier overall skin quality The key concept is that these visible improvements are thought to stem from underlying tissue-support mechanisms rather than temporary cosmetic changes

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Rasmusson AM, Shi L, Duman R

So a hormone that does something on one cell is likely to do something else on another cell to, as a negative feedback loop, to keep it from running out of control, to keep the, you know, equipoise in the system