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If once-daily convenience is required, longer-acting alternatives like modified GRF or CJC-1295 with DAC are more appropriate choices

Ipilimumab against cytotoxic T-lymphocyte antigen 4 (CTLA4), nivolumab and pembrolizumab against programmed death 1 (PD1) as well as atezolizumab against programmed death-ligand 1 (PD-L1) are approved by the FDA for the treatment for advanced melanoma either as monotherapy or combination therapy (166)

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bioRxiv Preprint at (2025)