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In addition, MEL was shown to inhibit phosphorylation of the ERK1/2 signaling pathway, which inhibited MMP-9 gene transcription by affecting the expression of transcription coactivators such as CREB-binding protein (CREBBP) and E1A p300-binding protein (EP300), as well as reducing histone acetylation in the cultures studied (238)

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They have a medical condition that requires a different treatment approach