Cyanocobalamin symptoms include irregular bowel movements, pain in the abdomen, excessive gas in the digestive tract
doi: 10.1038/s41467-017-02375-6 73 ChengJYangHLGuCJLiuYKShaoJZhuRet al
J Gastrointest
PMID: 228 SmithMDaiAGhilardiGAmelsbergKVDevlinSMPajarilloRet al
Where this leaves the stack BPC-157 and TB-500 are the two most-researched tissue-repair peptides, and the reason they are paired is a real one: they do different things, at different scales, through different mechanisms
FDA staff's own briefing document, posted publicly ahead of the meeting as part of the docket, proposes that TB-500 (free base) and TB-500 acetate not be added to the list, citing incomplete physicochemical characterization, a lack of evidence of effectiveness for wound healing (including an in-vitro fibroblast study in which TB-500 reportedly did not induce wound healing), and insufficient nonclinical and clinical safety data