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In a 2018 study involving 130 women with PCOS who underwent OI with LE (5 mg/day), oral administration of NAC (1.2 g/day) for 5 days significantly improved ovulation and pregnancy rates compared to placebo [54]

Amylin receptors are distinct from incretin receptors and are located in brainstem regions involved in appetite and satiety

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Oral semaglutide mimics this hormone and enhances its impact

Physical compression reduces fluid retention in tissue spaces and prevents gravity from causing swelling to shift downward

Peer review Peer review information Nature Reviews Endocrinology thanks Jonathan Campbell and the other, anonymous, reviewer(s) for their contribution to the peer review of this work