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semaglutide 1.0 mg was discontinued before the last dose because of use of prescription or non-prescription systemic products or topical medicinal products within 3 weeks prior to the visit' and one subject randomised to placebo was discontinued after the last dose because of a serious AE (traffic accident

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Overall, due to the lack of clinical trials, arginase inhibitors are not currently recommended for the prevention or treatment of cardiovascular disease in clinical practice guidelines