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These results are backed up by the finding of a strong increase of the concentration of Pycnogenol s metabolites and components in the synovial fluid, surrounding articular cartilage in the joints in osteoarthritis patients (71, 72)

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4 Discussion Considering the clinical utility of low serum GPX-3 concentration (or GPX-3 deficiency) in various diseases, in this study we investigated whether serum GPX-3 concentration at diagnosis could be used to assess vasculitis activity and damage at diagnosis in immunosuppressive drug-naive patients with AAV, and obtained some interesting findings