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If the medication is acidic or contains specific preservatives, it can temporarily irritate the surrounding cells

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Smart N, et al

Am J Kidney Dis 41(4 Suppl 4):S412 Huang D, Zhao Q, Liu H, Guo Y, Xu H, PPAR- Agonist (2016) WY-14643 inhibits LPS-Induced inflammation in synovial fibroblasts via NF-kB pathway

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However, whether these effects are the result of the drug or due to the presence of concomitant diseases is not known for certain