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Tirzepatide (Mounjaro/Zepbound) Potential: Newer research reviews (2025) have highlighted Tirzepatidewhich targets both GLP-1 and GIP receptorsas a potential "disease-modifying" therapy

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As weak agonists tend to become partial agonists when receptor density is limited 32 , this may indicate failure of the slowly internalizing compounds to maximally exploit the residual surface receptors

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease