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Case reports from the 1970s published in JAMA [291,292,293,294,295] initiated animal [296] and human [297,298] studies contradicting any relevant interaction

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The dual role of IL-22 in UC IL-22 could be produced by immune cells like Th17 cells on mucosal surfaces, and its role in maintaining intestinal barrier homeostasis is a topic of debate

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Evaluation of compound 2 stability under the biochemical assay conditions with recombinant TGR TGR assay solutions (1 ml each) were prepared as described in the main manuscript