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The researchers also conducted RNA-sequencing, which apparently pointed to reduced activity of pathways involved in ECMreceptor interaction and focal adhesion, alongside lower levels of key ECM proteins such as fibronectin, tenascin C, laminin, thrombospondin-2, and Hmmr

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In terms of outcome assessment, 18 (6.8%) studies applied DHTs to facilitate timely evaluation of therapeutic interventions, including patient-reported outcomes and digitally captured functional measures

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