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However, not all studies were included in each analysis due to lack of reporting on all outcomes by each individual study (see Supplementary Material Tables S5S7)

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Semaglutide, the active ingredient in Ozempic, has demonstrated clinically significant reductions in visceral belly fatthe dangerous deep abdominal fat linked to heart disease and diabetes

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Beyond appetite reduction, semaglutide improves insulin sensitivity at the cellular level, lowering circulating insulin and reducing androgen production

In prior studies aggregating Phase III clinical trial data, the degree of VAT reduction was associated with lowering of HbA1c (29), suggesting that ongoing reduction in ectopic fat, as well as increasing lean body mass, may ultimately counterbalance initial increases in glucose