PubMed Martinotti G, Andreoli S, Reina D, Di Nicola M, Ortolani I, Tedeschi D, Fanella F, Pozzi G, Iannoni E, D'Iddio S, Prof LJ
A 72% increase in self-reported sleep quality was found for the treatment group, compared with 29% in the placebo group
Acknowledgements We gratefully acknowledge the patients and their families for participation in this study
doi:10.1186/s40662-016-0063-5
Development involved developing matrix and drug reservoir type transdermal patches using i) several polymers such as Polyethylene glycol, methacrylate copolymers (Eudragits), Acrylic copolymer, Polyster Film/copolymer of ethylene and vinyl acetate, Poly(Butyl methacrylate, methyl methacrylate), cellulose (Ethyl cellulose, Hydroxypropylmethylcellulose Polyvinylpyrrolidone etc
Furthermore, the dual inhibition of glutaminase and CPT1 has been shown to reduce the proliferation and migration of CB-839-resistant cells in comparison to the inhibition of individual enzymes
