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There was no need to evaluate the inconsistency between the direct (any class of drugs vs another class) and indirect (any class of drugs vs placebo) effects in the network meta-analysis, as there was no trial that compared any two classes in all the trials
Additional signaling pathways that melatonin can affect include upregulation of nuclear factor erythroid 2-related factor 2 (NRF2), the activation of the Toll-like receptor-4 (TLR4) and the high-mobility group box-1 (HMG-1) signaling receptors, and inhibition of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome [54]
The advantage of propionibacteria is their ability to synthesize vitamin B 12 as well
