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For instance, while ultrasound-targeted microbubble destruction (UTMD) systems for GDNF or BDNF gene delivery show synergistic neuroprotective effects in PD models, simultaneous GDNF/BDNF delivery did not show additional benefits, possibly due to competing expressions (Lin et al., 2020)

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doi: 10.2337/db14-0302 37 BurmeisterMAAyalaJDruckerDJAyalaJE

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