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Allergy-wise, there are some case reports on neem oil causing allergic contact dermatitis so people with plant/botanical sensitivities may want to patch test first

Because junk-food diets are nutrient-poor, depletion of micronutrients with critical pharmacological/biochemical roles (e.g., zinc) will be expected to both heighten oxidative stress and blunt the activity of zinc-dependent enzymes essential for normal spermatogenesis, effects beyond simple loss of antioxidant buffering

Limitations: No joint-specific human RCTs

References National Center for Biotechnology Information

Health history, current goals, contraindication screening

Regular sessions may be needed to sustain the results