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Reports were similar from animal studies testing the effect of leptin sensitizers targeting the protein tyrosine phosphatase-1B (PTP1B)(9)(10) or the chemical chaperones that repair ER stress, including 4-phenyl butyric acid (PBA) and tauroursodeoxycholic acid (TUDCA) (11), each of which demonstrated reduced food intake and body weight

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In our study, taurine levels were reduced, consistent with previous findings of decreased taurine in the PFC of a rat model of depression 89

European Journal of Pharmacology, 970 , Article 176476