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Common sites for transdermal patches include the abdomen (avoiding waistline and navel), outer upper arm, anterior or lateral thigh, and upper back or shoulder area
Phase 3 results are expected throughout the remainder of the TRIUMPH program, with potential FDA approval estimated for 2027 at the earliest
There could be a placebo effect, Jay says
For tirzepatide (Zepbound) Jastreboff and colleagues reported in the New England Journal of Medicine in 2022 that at maximal doses, the percent of individuals reporting side effects were as follows: Nausea 31.0% Diarrhea 23.0% Vomiting 12.2% Constipation 11.7% Bettge and colleagues conducted a study published in Diabetes, Obesity, and Metabolism in 2017 that showed that individuals who were taking metformin while taking a GLP-1 were more likely to have side effects, especially nausea and vomiting
Many people miss this distinction upfront, so lets break both down clearly
