Primary Intracellular Thiol: Serves as a major redox buffer in cells, often present at millimolar levels in many cell types
Glutathione is the bodys primary detoxification molecule, directly supporting liver function and the clearance of environmental toxins, heavy metals, and metabolic waste
doi: 10.1155/2020/8817778 66
Sadgrove NJ, Simmonds MSJ
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
DHAR and GR activities convert the DHA translocated from the lumen and the DHA generated in the stroma to AsA (Asada, AsA-GSH pathway in mitochondria The presence and activity of AsA-GSH cycle enzymes in mitochondria of plant cells have been established, and this cycle plays an important role in protecting mitochondrion against the toxic ROS regularly produced in respiratory chain reactions (Leonardis et al., 2000