Khaw SC, Wong ZZ, Anderson R, Martins da Silva S
Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes
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Interestingly, both estradiol and leptin receptors colocalize in kisspeptinergic neurons, which are considered to be the link between nutrition (metabolism) and reproduction (ovulatory function) (151)
Significant increases in various classes of metabolites (butyrates, carnitines, BCAAs, organic acids) are possibly required not only as energy substitutes, but also for active gluconeogenesis, to maintain blood glucose levels during fasting 31
Several excellent reviews have highlighted results of clinical trials using DPP4 inhibitors to treat type 2 diabetes (6)
