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Simulation of stress through pulse treatment with dexamethasone/adrenaline reproduced the regeneration failure, while inhibition of the stress response with anxiolytic drugs partially rescued the regenerative process 55

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Furthermore, BG expressively elevated pro-apoptotic enzyme expressions (Bax, caspase-9, and caspase-3), while attenuating the B-cell lymphoma/leukemia type 2 (Bcl-2), inflammatory cytokines, and PI3K/Akt/mTOR signalling