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It contains a high density of glucocorticoid receptors and plays a critical role in HPA-axis feedback control

However, B12 issues can be caused by taking some types of stomach acid blockers

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Vitamins B12 and B6 and BCAAs are generally safe in high doses, and any excess is simply excreted

Using multiple high-throughput proteomics assays in two independent cohorts of konzo-affected children compared to unrelated individuals (Discovery) or their unaffected sibling (Validation) respectively, we demonstrate that levels of the critical plasma-based antioxidant enzyme Glutathione Peroxidase 3 (GPx3) are significantly reduced in those affected