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Several key metabolic pathways, including NAD + biosynthesis, fatty acid transport, carnitine shuttle, and -oxidation, displayed impairments in kidneys of cKOt mice, resulting in perturbed mitochondrial activity

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The full side-effect profile may evolve as larger and longer-duration studies are completed

Summer temperatures exceeding 30C dramatically accelerate degradation

Future research directions Given the notable comorbidity of IBD and liver disease, further studies are necessary to elucidate this underlying connection