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Therefore, low glutathione levels can contribute to the inefficiency of methylation, creating a vicious cycle and furthering depleting ones glutathione levels

Glutathione, a crucial endogenous antioxidant, has been proposed as a potential neuroprotective agent capable of mitigating MDMA-induced cerebral damage.Sixty adult male Wistar rats were randomly assigned to six experimental groups and administered oral treatments for 56 days: MDMA (5 mg/kg or 15 mg/kg), glutathione (15 mg/kg), or their combinations

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Moreover, HGF gene transfer with viral vectors reduces pain and inflammation in a neuropathic model (Tsuchihara et al., 2008), promotes neurite extension, and increases synaptogenesis in a stroke model (Shimamura et al., 2006)