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31 Lastly, genetic profiling did not reveal BRAF- V600E mutations, which are commonly associated with metastatic spinal melanoma and may help differentiate MMNSTs from other melanotic spinal tumors like metastatic spinal melanoma

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Interventions such as the antioxidant NAC or the inhibition of MAPK8/JNK activity have been demonstrated to mitigate ROS-induced parthanatos in glioma cells [156], suggesting that MAPK8 activation contributes to parthanatos by enhancing intracellular ROS levels

This review synthesizes cross-disciplinary evidence to propose a novel hypothetical framework: the gut microbiota-ferroptosis axis as a driver of OA progression