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"Some patients find that injecting in the evening helps reduce nausea," she says, noting that light carbohydrates like crackers can help settle the stomach

A study in Diabetes, Obesity and Metabolism found patients who discontinued GLP-1 therapy regained about two-thirds of their lost weight within one year

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Because of the risk of low blood sugar, Shah says, its really important to work with a doctor on dosing of both the GLP-1 and insulin