For skin, the primary mechanisms include stimulation of collagen I and III synthesis, increased production of decorin (which organizes collagen fibers), upregulation of VEGF for blood vessel formation, and activation of tissue remodeling through metalloproteinase regulation
A typical approach might begin with Retatrutide alone for 4 to 8 weeks, add BPC-157 during dose escalation when GI symptoms peak, introduce TB-500 after reaching maintenance Retatrutide doses, and finally add GHK-Cu when significant weight loss begins affecting skin appearance
Vitamin B12 supports healthy blood cells and is also involved in energy metabolism and nervous system health
Lyophilized powder maintains stability for 2-3 years at freezer temperatures (-20C to -80C) or 1-2 years refrigerated at 2-8C
Vitamin B12 also keeps the nervous system healthy
The authors have declared that no competing interests exist