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7 Other studies have shown an association with GLP-1 RAs and lower obesity-related cancer risk, 8 and preliminary data suggest no increased recurrence risk and possible cardiovascular benefits
Interpatient variability in bioavailability is related to the extent of absorption: implications for bioavailability and bioequivalence studies
Tests may include liver, renal and thyroid function 2-5
On the other hand, and seemingly paradoxically in rats the CB1R agonist WIN 55,212-2 enhanced the anorexigenic effects of subthreshold doses of the GLP1-RA exendin-4 resulting in a significant decrease in food intake and body weight in rats [61]
The bottom line: With appropriate monitoring (especially in patients with active suicidal ideation or severe eating disorders), GLP-1s appear safe from a psychiatric standpoint
Lurasidone has a lower risk of weight gain and metabolic complications than many other atypical antipsychotics
