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Central Nervous System Effects : These medications interact with GLP-1 receptors in the hypothalamus and other brain regions that regulate appetite and energy homeostasis

Effects of exenatide once weekly plus dapagliflozin, exenatide once weekly alone, or dapagliflozin alone added to metformin monotherapy in subgroups of patients with type 2 diabetes in the DURATION-8 randomized controlled trial

| Concentration | BAC Water | Doses at 0.5mg | Doses at 1.0mg | |---------------|-----------|----------------|----------------| | 5mg/mL (recommended) | 1.0mL | 10 doses | 5 doses | | 2.5mg/mL | 2.0mL | 10 doses | 5 doses | **Best practice:** Use 1.0mL BAC water (5mg/mL)

Moreover, the regulatory frameworks for innovative multi-target therapies are complex, necessitating extensive safety databases including varied patient demographics

J Clin Endocrinol Metab (2021) 106(3):91221

At 12mg weekly doses, you will use most of a vial before stability becomes a concern