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In Phase 1 studies, survodutide was generally well tolerated, with no significant safety or tolerability issues observed in either healthy individuals with overweight or obesity [87, 88]

Sunday sucked, but Monday was better

Various reports show rates of recurrence ranging from 16% to 52%

What this means for you: The biology is more credible than critics often acknowledge, but the human data isn't there yet, and the regulatory risks are real

Reduced oxidative stress and increased in vitro oocyte maturation was also observed in women (Leito et al., 2024)

More direct evidence of this effect was identified by Vasu et al., which reported that alpha-cell proliferation in response to STZ-treatment was specifically associated with an increase in GLP-1 + alpha-cells (102)