Haverty T, Wyatt DJ, Porter KM, Leubitz A, Banks K, Goodyer P, Hu MY (2021) Phase 1 renal impairment trial results supports targeted individualized dosing of ELX-02 in patients with nephropathic cystinosis
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Borowczyk, K., Krawczyk, M., Kubalczyk, P
This in turn, first activates the PI3K/Akt/mTOR, PI3K/Akt/FoxO, or Ras/MAPK/(ERK-1/2) pathways that have important roles in cancer cell growth and carcinogenesis
This time dependency hampers the comparison of potency or toxicity between compounds and between different organisms
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