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NNMT plays a role in regulating nicotinamide adenine dinucleotide (NAD+) metabolism, energy expenditure, and cellular signaling pathways

Before taking Vitamin B12 Injection, inform your doctor if you: Are allergic to Vitamin B12 or cobalt Have any other food or medicine allergies An eye disease called as Leber's optic neuropathy A slow growing blood cancer where your bone marrow makes too many red blood cells (polycythemia vera) Gout (high uric acid levels in body) Iron or folic acid deficiency anemia Low potassium levels in your blood Drug interactions It is important to tell your healthcare professional about all other medicines that you have taken recently including any kind of supplements and non-prescription drugs

How we reviewed this article: Current Version October 03, 2025 Written By John DiBella Fact-checked By Dr

Its always a good practice to inform your healthcare provider about all medicines, vitamins, and supplements you are using

However, serum levels were higher in people prescribed valproate

As fat tissue grows and more NNMT is produced, higher amounts of hormones and pro-inflammatory signals are produced that are responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. NNMT is responsible for converting nicotinamide (NA) into 1-methylnicotinamide (1-MNA), which takes it out of the NAD salvage pathway (see the diagram below)