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Acetaminophen is toxic to hepatocytes because of the production of the intermediate, NAPQI, by cytochrome P450 enzymes

In addition, the characterized LASSS treatment did not stimulate autolysis of HGF as monitored by SDS-PAGE for degradation of 60-kDa -chain and 90-kDa proform of recombinant HGF incubated with LASSS (at 1:8000) at 25 for 2 h (see supplementary Figure 1b), providing another important basis for the availability of LASSS-HGF

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This induces autophagy and mitophagy in the skeletal muscle of aged mice and improves muscle mass

Talley LI, Soong S-j, Harrison RA, McCarthy WH, Urist MM, Balch CM: Clinical Outcomes of Localized Melanoma of the Foot: A Case-Control Study