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doi: 10.1016/j.rasd.2013.09.006
Beyond the extensively studied NRF2 pathway, which has been developed as a therapeutic target [502, 503], the PI3K/AKT/mTOR signaling pathway also plays a crucial role in cell survival and metabolism
Keating says that more testing is needed to determine how effective the drugs might be in combating specific cancers, whether the drugs would be most effective in combination with others or on their own, and whether they should be used as first-line drugs or when cancers become resistant to other drugs
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