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Additionally, these medications may alter food preferences, with many patients reporting reduced cravings for high-fat and high-sugar foods

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Carnitine supplementation with 10-50 mg/kg/day significantly reduced symptoms of constipation

Patients with a history of diabetic retinopathy should be monitored for progression of diabetic retinopathy Hypoglycemia: Patients receiving RYBELSUS in combination with an insulin secretagogue (e.g., sulfonylurea) or insulin may have an increased risk of hypoglycemia, including severe hypoglycemia

In 2017, Murata and collaborators reported that serum carnitine level was negatively correlated with severity of constipation in 27 patients