In Manduca sexta , an antenna specific GST, GST-msolf1 is expressed in the sex-pheromone-sensitive sensilla and can modify trans -2-hexenal, a plant derived green leaf aldehyde, suggesting its dual role in protecting sphinx moth olfactory system from harmful xenobiotics and pheromone inactivation [107]
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(PubMed) Stephen R, Utecht T
Similarly, refrain from its use if diagnosed with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), or if you've previously experienced a severe allergic reaction to tirzepatide or any of its components
Generally, if a product with an orphan drug designation subsequently receives the first regulatory approval for the indication for which it has such designation, the product is entitled to a period of marketing exclusivity, which precludes the FDA or the EMA (as applicable) from approving another marketing authorization application for another similar product candidate for the same orphan therapeutic indication for that time period
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